Ruxolitinib - INCB 018424 phosphate

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 1598

CAS [1092939-17-7]

MF C17H18N6.H3O4P
MW 404.36

Purity: 99%
Optical purity: 98% ee
Soluble in water and DMSO

Ruxolitinib

Description

An orally bioavailable, potent and selective inhibitor of Janus-associated kinase (JAK) 1 and 2, with IC50 to be 2.7, 4.5 and 332 nM for JAK1, JAK2 and JAK3 respectively; selectivity >100 fold for a wide range of other kinases. It acts by blocking the JAK/STAT pathway

RA Mesa. Ruxolitinib, a selective JAK1 and JAK2 inhibitor for the treatment of myeloproliferative neoplasms and psoriasis. IDrugs. 2010, 13(6), 394-403.

C Campas-Moya. Ruxolitinib. Drugs Fut. 2010, 35(6), 457.

S Verstovsek et al. Safety and efficacy of INCB018424, a JAK1 and JAK2 inhibitor, in myelofibrosis. N. Engl. J. Med. 2010, 363(12), 1117-1127.

A Quintas-Cardama et al. Preclinical characterization of the selective JAK1/2 inhibitor INCB018424: therapeutic implications for the treatment of myeloproliferative neoplasms. Blood 2010, 115(15), 3109-3117.

E Apostolidou et al. JAK2 inhibitors: a reality? a hope? Clin. Lymp Myel. 2009, 9(Suppl. 3), S340-S345.

JAK1 and JAK2 inhibitor

Chemical name

(R)-3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile phosphate

Parent CAS No.

[941678-49-5]

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2 mg	€65.00	In Stock
5 mg	€90.00	In Stock
25 mg	€270.00	In Stock

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Size	Unit Price	Stock
2 x 5 mg	€130.00	In Stock
2 x 25 mg	€400.00	In Stock

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Ruxolitinib - INCB 018424 phosphate

Description

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Parent CAS No.

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