Cerdulatinib - PRT 062070

Based on 10 reference(s) in Google Scholar 8 10 10

Axon 2775

CAS [1198300-79-6]

MF C20H27N7O3S
MW 445.54

  • Purity: 98%
  • Soluble in DMSO
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Cerdulatinib

Description

Cerdulatinib is an orally active kinase inhibitor that demonstrates activity against Syk and JAK with IC50 values of 32 nM, 12 nM, 6 nM and 8 nM for Syk, JAK1, JAK2 and JAK3, respectively. Cellular assays demonstrated specific inhibitory activity against signaling pathways that use Syk and JAK1/3. Limited inhibition of JAK2 was observed. Potent antitumor activity was observed in a subset of B-cell lymphoma cell lines.

KEYWORDS: Cerdulatinib | support | Syk/JAK inhibitor | PRT 062070 | PRT062070 | PRT-062070 | CAS [1198300-79-6] | CAS [1369761-01-2] | B-Cell Transformation | Spleen tyrosine kinase (Syk) | JAK | Inhibitor | Enzymes | B-cell lymphoma

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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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