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P 505-15
- PRT 062607
Axon 1936
CAS:
1370261-96-3
- Optical Purity: Optically pure
- Soluble in DMSO
- MF: C19H23N9O
- MW: 393.45
Description
Highly specific and potent inhibitor of spleen tyrosine kinase (Syk) (IC50: 1-2 nM)
More Information
| Parent CAS No. | 1370261-96-3 |
|---|---|
| Chemical Name | 4-(3-(2H-1,2,3-triazol-2-yl)phenylamino)-2-((1R,2S)-2-aminocyclohexylamino)pyrimidine-5-carboxamide |
| SMILES | C1(N[C@@H]2CCCC[C@@H]2N)=NC=C(C(N)=O)C(NC2=CC=CC(N3N=CC=N3)=C2)=N1 |&1:2,7,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C19H23N9O/c20-15-6-1-2-7-16(15)26-19-22-11-14(17(21)29)18(27-19)25-12-4-3-5-13(10-12)28-23-8-9-24-28/h3-5,8-11,15-16H,1-2,6-7,20H2,(H2,21,29)(H2,22,25,26,27)/t15-,16+/m0/s1 |
| InChiKey | TXGKRVFSSHPBAJ-JKSUJKDBSA-N |
| CID | 44462758 |
| Short Description | Syk inhibitor |
References
- G Coffey et al. Specific Inhibition of Spleen Tyrosine Kinase Suppresses Leukocyte Immune Function and Inflammation in Animal Models of Rheumatoid Arthritis. J. Pharmacol. Exp. Ther. 2012, 340(2), 350-359.
- J Hoellenriegel et al. Selective, novel spleen tyrosine kinase (Syk) inhibitors suppress chronic lymphocytic leukemia B-cell activation and migration.
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