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JAK2 inhibitor 13

 - Sulfonamide 13
Axon 1843
CAS:  1110502-30-1
Purity:  99%
  • Soluble in DMSO
  • MF:  C17H20N4O2S
  • MW:  344.43

Description

Potent and selective Janus Kinase 2 (JAK2) inhibitor; inhibits the activity of both the wild-type JAK2 and the V617F mutant (IC50 = 78 and 206 nM, respectively), with >35-fold selectivity versus JAK3 (IC50 = 2.93 µM)

More Information

Parent CAS No. 1110502-30-1
Chemical Name 4-(3-amino-1H-indazol-5-yl)-N-tert-butylbenzenesulfonamide
SMILES C1(C2C=CC(S(=O)(=O)NC(C)(C)C)=CC=2)C=C2C(N)=NNC2=CC=1
MFCD N.A.
InChi InChI=1S/C17H20N4O2S/c1-17(2,3)21-24(22,23)13-7-4-11(5-8-13)12-6-9-15-14(10-12)16(18)20-19-15/h4-10,21H,1-3H3,(H3,18,19,20)
InChiKey KFJCXIOVAGJCKB-UHFFFAOYSA-N
CID 24963047
Short Description JAK2 inhibitor

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