Bulk Inquiry
TG 101348
- Fedratinib - SAR 302503
- Soluble in DMSO
- MF: C27H36N6O3S
- MW: 524.68
Description
An orally bioavailable, ATP-competitive and selective inhibitor of Janus-associated kinase 2 (JAK2, IC50: ca 3 nM) with potential antineoplastic activity.
More Information
| Parent CAS No. | 936091-26-8 |
|---|---|
| Chemical Name | N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)ethoxy)phenylamino)pyrimidin-4-ylamino)benzenesulfonamide |
| SMILES | C1(S(=O)(=O)NC(C)(C)C)C=C(NC2N=C(NC3C=CC(OCCN4CCCC4)=CC=3)N=CC=2C)C=CC=1 |
| MFCD | MFCD12922515 |
| InChi | InChI=1S/C27H36N6O3S/c1-20-19-28-26(30-21-10-12-23(13-11-21)36-17-16-33-14-5-6-15-33)31-25(20)29-22-8-7-9-24(18-22)37(34,35)32-27(2,3)4/h7-13,18-19,32H,5-6,14-17H2,1-4H3,(H2,28,29,30,31) |
| InChiKey | JOOXLOJCABQBSG-UHFFFAOYSA-N |
| CID | 16722836 |
| Short Description | JAK2 inhibitor |
References
- A Mullally et al. Physiological Jak2V617F expression causes a lethal myeloproliferative neoplasm with differential effects on hematopoietic stem and progenitor cells. Cancer Cell. 2010 Jun 15;17(6):584-96.
- G Wernig et al. Efficacy of TG101348, a Selective JAK2 Inhibitor, in Treatment of a Murine Model of JAK2V617F-Induced Polycythemia Vera. Cancer Cell 2008, 13, 311–320.
- List of publications using TG 101348 (Axon 1588) purchased from Axon Medchem
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