GLPG-0634 - Filgotinib

Based on 193 reference(s) in Google Scholar 8 10 193

Axon 4006

CAS [1206161-97-8]

MF C21H23N5O3S
MW 425.50

  • Purity: 99%
  • Soluble in DMSO



GLPG-0634 is the first orally-available, selective inhibitor of JAK1. In vitro, it selectively inhibits JAK1 and JAK2 with IC50 values of 10 nM and 28 nM, respectively, selective over JAK3 and TYK2 (IC50 Values of 810 nM and 116 nM, respectively), and a panel of 150 other kinases. However, when tested in vivo it selectively inhibits JAK1, displaying a 30-fold potency over JAK2.

KEYWORDS: GLPG-0634 | Supplier | JAK1 inhibitor | Filgotinib | GLPG0634 | GLPG 0634 | G 146034 | G146034 | CT-GLPG | CAS [1206161-97-8] | JAK-STAT Pathway | JAK | Inhibitor | Enzymes

The first orally-available, selective inhibitor of JAK1

Chemical name


Source information

Sold in collaboration with Chemietek

Parent CAS No.


The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

Please wait...