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Baricitinib

 - INCB 028050  - LY 3009104
Axon 1955
CAS:  1187594-09-7
Purity:  99%
  • Soluble in 0.1N HCl(aq) and DMSO
  • MF:  C16H17N7O2S
  • MW:  371.42

Description

Selective and orally bioavailable JAK1/JAK2 inhibitor with nanomolar potency against JAK1 (5.9 nM) and JAK2 (5.7 nM); INCB028050 inhibits intracellular signaling of multiple proinflammatory cytokines including IL-6 and IL-23 at concentrations <50 nM

More Information

Certificate of Analysis

Material Safety Data Sheet

Parent CAS No. 1187594-09-7
Chemical Name 2-(3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-1-(ethylsulfonyl)azetidin-3-yl)acetonitrile
SMILES N1(S(CC)(=O)=O)CC(N2C=C(C3N=CN=C4NC=CC4=3)C=N2)(CC#N)C1
MFCD N.A.
InChi InChI=1S/C16H17N7O2S/c1-2-26(24,25)22-9-16(10-22,4-5-17)23-8-12(7-21-23)14-13-3-6-18-15(13)20-11-19-14/h3,6-8,11H,2,4,9-10H2,1H3,(H,18,19,20)
InChiKey XUZMWHLSFXCVMG-UHFFFAOYSA-N
CID 44205240
Short Description JAK1/2 inhibitor

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