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XE 991 dihydrochloride
- Parent CAS: 122955-42-4
- Soluble in DMSO
- MF: C26H20N2O.2HCl
- MW: 449.37
Description
XE 991 dihydrochloride is a KCNQ/Kv7 potassium channel blocker that inhibits the neuronal M-current.
Kv7-mediated M-currents stabilize membrane potential and regulate neuronal excitability. XE 991 is widely used to evaluate M-current contributions to firing behavior, synaptic responsiveness and cholinergic modulation.
Key Features
- Blocks KCNQ/Kv7 potassium channels
- Inhibits neuronal M-current
- Useful for excitability and firing-pattern studies
- Relevant to CNS potassium channel pharmacology
Applications
- KCNQ/Kv7 electrophysiology
- M-current inhibition studies
- Neuronal excitability models
- Epilepsy and cholinergic signaling research
XE991 hydrochloride is the water soluble salt of the parent molecule XE 991 (Axon 1987) that is also available from Axon Medchem.
More Information
| Parent CAS No. | 122955-42-4 |
|---|---|
| Chemical Name | 10,10-bis(pyridin-4-ylmethyl)anthracen-9(10H)-one dihydrochloride |
| SMILES | C1C=C2C(=O)C3C=CC=CC=3C(CC3C=CN=CC=3)(CC3C=CN=CC=3)C2=CC=1.Cl.Cl |
| MFCD | MFCD09055426 |
| InChi | InChI=1S/C26H20N2O.2ClH/c29-25-21-5-1-3-7-23(21)26(17-19-9-13-27-14-10-19,18-20-11-15-28-16-12-20)24-8-4-2-6-22(24)25;;/h1-16H,17-18H2;2*1H |
| InChiKey | WOGWMARIFDNZON-UHFFFAOYSA-N |
| CID | 45073462 |
| Short Description | KCNQ blocker |
References
- Wang et al. KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the M-channel. Science 1998, 282 1890.
- Zaczek et al. Two new potent neurotransmitter release enhancers, 10,10-bis(4-pyridinylmethyl)-9(10H)-anthracenone and 10,10-bis(2-fluoro-4-pyridinylmethyl) -9(10H)-anthracenone: comparison to linopirdine. J. Pharmacol. Exp. Ther. 1998, 285 724.
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