AVE 0118 hydrochloride

Based on 8 reference(s) in Google Scholar 9 10 8

Axon 2243

CAS [2108821-80-1]

MF C30H29N3O3.HCl
MW 516.03

  • Purity: 99%
  • Soluble in water and DMSO

AVE 0118 hydrochloride


Potassium channel blocker. AVE0118 caused concentration-dependent inhibition of Kv1.5 (IKur), Kv4.3 (Ito), Kir3.4 (IKAch), and IKr currents (IC50 values 6.2 μM, 3.4 μM, 4.5 μM, and 10 μM resp.). A potent and atrium selective antiarrhythmic compound with no apparent effect on ventricular repolarization. Noteworthy, the atrial selective and dose-dependent prolongation of atrial refractoriness (ERP) by AVE 0118 has been claimed to be an inhibitory effect of sodium channel activity in an atrial-selective manner, and may therefor contribute to anti-AF properties of AVE0118.

KEYWORDS: AVE 0118 hydrochloride | IKur channel blocker | AVE0118 | AVE-0118 | CAS [2108821-80-1] | [498577-53-0] | Potassium | Kv1.5 | Kv4.3 | Kir4.3 | Blocker | Ion Channels | KCNA5 | KCND3 | KCNJ5 | KCNE1 | Voltage gated | Antiarrhythmic | Atrial | Refractoriness | ERP

Size Unit Price Stock
5 mg €120.00 In Stock
25 mg €420.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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