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XE 991
- Soluble in DMSO
- MF: C26H20N2O
- MW: 376.45
Description
KCNQ channel and M-current blocker; potential AD therapeutic. The hydrochloride salt of XE 991 (Axon 1305) is available as well.
More Information
| Parent CAS No. | 122955-42-4 |
|---|---|
| Chemical Name | 10,10-bis(pyridin-4-ylmethyl)anthracen-9(10H)-one |
| SMILES | C1C=C2C(=O)C3C=CC=CC=3C(CC3C=CN=CC=3)(CC3C=CN=CC=3)C2=CC=1 |
| MFCD | MFCD05662331 |
| InChi | InChI=1S/C26H20N2O/c29-25-21-5-1-3-7-23(21)26(17-19-9-13-27-14-10-19,18-20-11-15-28-16-12-20)24-8-4-2-6-22(24)25/h1-16H,17-18H2 |
| InChiKey | KHJFBUUFMUBONL-UHFFFAOYSA-N |
| CID | 656732 |
| Short Description | KCNQ blocker |
References
- Wang et al. KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the M-channel. Science 1998, 282 1890.
- Zaczek et al. Two new potent neurotransmitter release enhancers, 10,10-bis(4-pyridinylmethyl)-9(10H)-anthracenone and 10,10-bis(2-fluoro-4-pyridinylmethyl) -9(10H)-anthracenone: comparison to linopirdine. J. Pharmacol. Exp. Ther. 1998, 285 724.
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