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CNQX disodium salt
- Parent CAS: 115066-14-3
- Soluble in water and DMSO
- MF: C9H2N4Na2O4
- MW: 276.12
Description
CNQX disodium salt is a competitive antagonist of AMPA and kainate ionotropic glutamate receptors. It blocks fast excitatory synaptic transmission mediated by non-NMDA glutamate receptor channels. It is a water-soluble sodium salt form of CNQX (Axon 1200).
AMPA and kainate receptors mediate rapid excitatory neurotransmission, synaptic plasticity and excitotoxic responses in the CNS. CNQX disodium salt is useful for electrophysiology, neuropharmacology and glutamate receptor subtype-dissection experiments.
Key Features
- Competitive AMPA/kainate receptor antagonist
- Blocks non-NMDA ionotropic glutamate receptor signaling
- Water-soluble CNQX derivative for electrophysiology workflows
- Useful for suppressing fast excitatory synaptic currents
Applications
- Glutamate receptor pharmacology
- Synaptic transmission and electrophysiology studies
- Excitotoxicity and neuronal circuit research
- AMPA versus NMDA pathway dissection
More Information
| Parent CAS No. | 115066-14-3 |
|---|---|
| Chemical Name | sodium 6-cyano-7-nitroquinoxaline-2,3-bis(olate) |
| SMILES | C12N=C([O-])C([O-])=NC1=CC([N+]([O-])=O)=C(C#N)C=2.[Na+].[Na+] |
| MFCD | N.A. |
| InChi | InChI=1S/C9H4N4O4.2Na/c10-3-4-1-5-6(2-7(4)13(16)17)12-9(15)8(14)11-5;;/h1-2H,(H,11,14)(H,12,15);;/q;2*+1/p-2 |
| InChiKey | YCXDDPGRZKUGDG-UHFFFAOYSA-L |
| CID | 6093155 |
| Short Description | AMPA/Kainate antagonist |
References
- Honore et al. Quinoxalinediones: Potent competitive non-NMDA glutamate receptor antagonists. Science 1988, 241, 701.
- Long et al. Effect of 6-cyano-2,3-dihydroxy-7-nitro-quinoxaline (CNQX) on dorsal root-, NMDA-, kainate- and quisqualate-mediated depolarization of rat motoneurones in vitro. Br. J. Pharmacol. 1990, 100, 850-854.
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