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HA 14-1
- Soluble in DMSO and EtOH
- MF: C17H17BrN2O5
- MW: 409.23
Description
More Information
| Parent CAS No. | 65673-63-4 |
|---|---|
| Chemical Name | ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate |
| SMILES | C1(N)OC2=CC=C(Br)C=C2C(C(C#N)C(OCC)=O)C=1C(OCC)=O |
| MFCD | MFCD00218213 |
| InChi | InChI=1S/C17H17BrN2O5/c1-3-23-16(21)11(8-19)13-10-7-9(18)5-6-12(10)25-15(20)14(13)17(22)24-4-2/h5-7,11,13H,3-4,20H2,1-2H3 |
| InChiKey | SXJDCULZDFWMJC-UHFFFAOYSA-N |
| CID | 3549 |
| Short Description | Bcl-2 inhibitor |
References
- JL Wang et al. Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells. PNAS 2000, 97(13), 7124-7129.
- J Skommen et al. HA14-1, a small molecule Bcl-2 antagonist, induces apoptosis and modulates action of selected anticancer drugs in follicular lymphoma B cells. Leukemia Res. 2006, 30(3), 322–331.
- JM Doshi et al. Structure-activity relationship studies of ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate (HA 14-1), an antagonist for antiapoptotic Bcl-2 proteins to overcome (...). J. Med. Chem. 2006, 49(26), 7731-7739.
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