Torin 1

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 1833

CAS [1222998-36-8]

MF C35H28F3N5O2
MW 607.62

Purity: 98%
Poorly soluble in DMSO

Torin 1

Description

Highly potent, selective and ATP-competitive mTOR inhibitor, with IC50 to be 2 and 10 nM for mTORC1 and mTORC2 respectively; Torin1 exhibits 1000-fold selectivity for mTOR over PI3K (EC50 = 1800 nM) and exhibits 100-fold binding selectivity relative to 450 other protein kinases

Q Liu et al. Discovery of 1-(4-(4-Propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one as a Highly Potent, Selective mTOR Inhibitor for the Treatment of Cancer. J. Med. Chem. 2010, 53(19), 7146–7155.

Q Liu et al. Discovery of 9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phenyl)benzo[h][1,6]naphthyridin-2(1H)-one (Torin2) as a potent, selective, and orally available (mTOR) inhibitor for treatment of cancer. J. Med. Chem. 2011, 54(5), 1473-1480.

mTOR inhibitor

Chemical name

1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one

Parent CAS No.

[1222998-36-8]

Order

Size	Unit Price	Stock
5 mg	€90.00	In Stock
25 mg	€300.00	In Stock

Need more? Bulk Inquiry

Related Products

Axon ID	Name	Description	From price
1282	BAG 956	PI3K and PDPK1 inhibitor		€95.00
1334	PIK 75 hydrochloride	PI3K inhibitor (p110-α specific)		€70.00
1362	PIK 90	PI3K inhibitor (p110-α specific)		€85.00
1366	LY 294002	PI3K inhibitor		€70.00
1367	KU-55933	ATM inhibitor		€110.00
1377	GDC 0941 bismesylate	PI3K inhibitor		€85.00
1380	PI 103 hydrochloride	PI3K inhibitor (p110 specific)		€60.00
1417	TGX 221	PI3K inhibitor (p110 β specific)		€70.00
1424	AS 252424	PI3K inhibitor (p110-γ specific)		€85.00
1463	NU 7441	DNA-PK inhibitor		€40.00
1472	KU-0063794	mTOR inhibitor		€60.00
1495	CP 466722	ATM inhibitor		€70.00
1520	NVP-BBD130	Dual PI3K and mTOR kinase inhibitor		€125.00
1584	KU-0060648 trihydrochloride	DNA-PK inhibitor		Inquire
1596	GSK 2126458	Dual PI3K and mTOR inhibitor		€50.00
1699	Temsirolimus	mTOR inhibitor		€95.00
1718	Palomid 529	mTOR inhibitor		€90.00
1719	D 106669	Potent and selective PI3K inhibitor		€85.00
1782	GDC 0980	Dual PI3K and mTOR inhibitor		€80.00
1797	NVP-BKM120	Class I PI3K inhibitor		€90.00
1807	PKI 587	Dual PI3K and mTOR inhibitor		€90.00
1831	A 66	PI3K inhibitor (p110-α specific)		€95.00
1834	Torin 2	mTOR inhibitor		€90.00
1855	PF 04691502	PI3K and mTOR tyrosine kinase inhibitor		€90.00
1893	VE 821	Inhibitor of the DNA damage response kinase ATR		€80.00
2029	NVP-BGT226	Orally active dual PI3K/mTOR inhibitor		€120.00
2069	Rapamycin	Specific inhibitor of mTOR; binds to FKBP12		€85.00
2142	INK 128	Potent and selective mTOR inhibitor		€110.00
2425	MHY 1485	mTOR activator with an inhibitory effect on autophagy		€70.00
2604	KU-0060648	DNA-PK inhibitor		€135.00
2630	eCF309	Highly selective and potent inhibitor of mTOR signalling		€85.00
2951	XL 388	Highly potent, selective, ATP-competitive, and orally bioavailable mTOR inhibitor		€125.00
3628	MHY-1685	mTOR inhibitor; Senescence inhibitor		€50.00
3996	AZD2014	Orally bioavailable dual mTORC1/mTORC2 inhibitor		Inquire
4149	Everolimus	Selective and orally active mTOR1 inhibitor	Recently added	Inquire

Customer Support

Customer Services

About Axon Medchem

Contact Us

Torin 1

Description

Chemical name

Parent CAS No.

Customer Support

About Axon Medchem

Download Product Catalog

Follow Us

Customer Support

Customer Services

About Axon Medchem

Contact Us

Torin 1

Description

Chemical name

Parent CAS No.

Related Products

Customer Support

About Axon Medchem

Download Product Catalog

Follow Us

Send us a message

Contact Us