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XL 388
- Soluble in 0.1N HCl(aq) and DMSO
- MF: C23H22FN3O4S
- MW: 455.5
Description
Highly potent, selective, ATP-competitive, and orally bioavailable inhibitor of the mammalian target of rapamycin (mTOR) with an IC50 value of 9.9 nM. Moreover, XL 388 is an mTORC1/2 dual inhibitor which displayed good pharmacokinetics and oral exposure in multiple species with moderate bioavailability. XL 388 showed anti-cancer activity in preclinical osteosarcoma models and inhibited survival and proliferation of RCC cell lines and primary human RCC cells.
More Information
| Parent CAS No. | 1251156-08-7 |
|---|---|
| Chemical Name | (7-(6-Aminopyridin-3-yl)-2,3-dihydrobenzo[f][1,4]oxazepin-4(5H)-yl)(3-fluoro-2-methyl-4-(methylsulfonyl)phenyl)methanone |
| SMILES | C1(N)C=CC(C2C=C3CN(C(C4C(C)=C(F)C(S(C)(=O)=O)=CC=4)=O)CCOC3=CC=2)=CN=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C23H22FN3O4S/c1-14-18(5-7-20(22(14)24)32(2,29)30)23(28)27-9-10-31-19-6-3-15(11-17(19)13-27)16-4-8-21(25)26-12-16/h3-8,11-12H,9-10,13H2,1-2H3,(H2,25,26) |
| InChiKey | LNFBAYSBVQBKFR-UHFFFAOYSA-N |
| CID | 59604787 |
| Short Description | mTOR inhibitor |
References
- CS Takeuchi et al. Discovery of a novel class of highly potent, selective, ATP-competitive, and orally bioavailable inhibitors of the mammalian target of rapamycin (mTOR). J Med Chem. 2013 Mar 28;56(6):2218-34.
- YR Zhu et al. The anti-cancer activity of the mTORC1/2 dual inhibitor XL388 in preclinical osteosarcoma models. Oncotarget. 2016 Aug 2;7(31):49527-49538.
- Z Xiong et al. The preclinical assessment of XL388, a mTOR kinase inhibitor, as a promising anti-renal cell carcinoma agent. Oncotarget. 2017 May 2;8(18):30151-30161.
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