XL 388

Based on 5 reference(s) in Google Scholar 8 10 5

Axon 2951

CAS [1251156-08-7]

MF C23H22FN3O4S
MW 455.50

  • Purity: 99%
  • Soluble in 0.1N HCl(aq) and DMSO
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XL 388

Description

Highly potent, selective, ATP-competitive, and orally bioavailable inhibitor of the mammalian target of rapamycin (mTOR) with an IC50 value of 9.9 nM. Moreover, XL 388 is an mTORC1/2 dual inhibitor which displayed good pharmacokinetics and oral exposure in multiple species with moderate bioavailability. XL 388 showed anti-cancer activity in preclinical osteosarcoma models and inhibited survival and proliferation of RCC cell lines and primary human RCC cells.

KEYWORDS: XL 388 | supplier | mTOR inhibitor | XL388 | XL-388 | CAS [1251156-08-7] | [1777807-51-8] | Phosphatidylinositol | mTOR | Inhibitor | Enzymes | Osteosarcoma | RCC

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Size Unit Price Stock
5 mg €125.00 In Stock
25 mg €435.00 In Stock
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2 x 5 mg €200.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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