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INK 128
- MLN0128 - Sapanisertib
- Soluble in 0.1N HCl(aq) and DMSO
- MF: C15H15N7O
- MW: 309.33
Description
INK 128 (Sapanisertib) is a potent and selective ATP-competitive mTOR kinase inhibitor that blocks both mTORC1 and mTORC2 signaling. It inhibits downstream phosphorylation events controlling protein synthesis, growth and survival signaling.
mTOR integrates nutrient, growth factor and oncogenic PI3K/AKT pathway inputs. INK 128 is relevant for studying dual mTOR complex inhibition in cancer, metabolic regulation and resistance to rapamycin-like allosteric mTOR inhibitors.
Key Features
- ATP-competitive mTOR kinase inhibitor
- Blocks both mTORC1 and mTORC2 signaling
- Suppresses growth and survival pathway phosphorylation
- Useful comparator to rapalog pharmacology
Applications
- PI3K/AKT/mTOR pathway studies
- Cancer cell growth and survival assays
- mTORC1/mTORC2 signaling research
- Therapy-resistance model profiling
More Information
| Parent CAS No. | 1224844-38-5 |
|---|---|
| Chemical Name | 5-(4-amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)benzo[d]oxazol-2-amine |
| SMILES | C1=NC(N)=C2C(C3=CC=C4OC(N)=NC4=C3)=NN(C(C)C)C2=N1 |
| MFCD | MFCD22124893 |
| InChi | InChI=1S/C15H15N7O/c1-7(2)22-14-11(13(16)18-6-19-14)12(21-22)8-3-4-10-9(5-8)20-15(17)23-10/h3-7H,1-2H3,(H2,17,20)(H2,16,18,19) |
| InChiKey | GYLDXIAOMVERTK-UHFFFAOYSA-N |
| CID | 45375953 |
| Short Description | mTOR inhibitor |
References
- AC Hsieh, Y Liu et al. The translational landscape of mTOR signalling steers cancer initiation and metastasis. Nature 2012, 485, 55–61.
- K Jessen et al. Abstract B148: INK128 is a potent and selective TORC1/2 inhibitor with broad oral antitumor activity. Mol. Cancer Ther. 2009, 8(12), S1.
- MR Janes et al. Efficacy of the investigational mTOR kinase inhibitor MLN0128/INK128 in models of B-cell acute lymphoblastic leukemia. Leukemia. 2013, 27(3), 586-594.
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