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CDK inhibitor CR8
- (R)-CR8
- Optical Purity: 100% e.e.
- Soluble in 0.1N HCl(aq) and DMSO
- MF: C24H29N7O
- MW: 431.53
Description
CDK inhibitor CR8 is a potent cyclin-dependent kinase (CDK) inhibitor with IC50 values of 0.09, 0.072, 0.041, 0.11, 1.10 and 0.18 μM for CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E, CDK5/p25, CDK7/cyclin H and CDK9/cyclin T, respectively. Moreover, CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K.
More Information
| Parent CAS No. | 294646-77-8 |
|---|---|
| Chemical Name | (R)-2-(9-Isopropyl-6-(4-(pyridin-2-yl)benzylamino)-9H-purin-2-ylamino)butan-1-ol |
| SMILES | C1(C2C=CC(CNC3C4N=CN(C(C)C)C=4N=C(N[C@@H](CO)CC)N=3)=CC=2)N=CC=CC=1 |&1:19,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C24H29N7O/c1-4-19(14-32)28-24-29-22(21-23(30-24)31(15-27-21)16(2)3)26-13-17-8-10-18(11-9-17)20-7-5-6-12-25-20/h5-12,15-16,19,32H,4,13-14H2,1-3H3,(H2,26,28,29,30)/t19-/m1/s1 |
| InChiKey | HOCBJBNQIQQQGT-LJQANCHMSA-N |
| CID | 10224714 |
| Short Description | CDK inhibitor |
References
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