Your cart

There are no items in your shopping cart

L-TBOA ammonia salt - TBOA | (3S)-3-(Phenylmethoxy)-L-aspartic acid ammonia salt

Based on 12 reference(s) in Google Scholar 9 10 12

Axon 2427

CAS [N.A.]

MF C11H13NO5.NH3
MW 256.26

  • Purity: 99%
  • Optical purity: Optically pure
  • Soluble in water and DMSO

L-TBOA ammonia salt

Description

Very potent blocker for the human excitatory amino acid transporters (EAAT1–3; IC50 values 23 µM, 3.8 µM, 7.0 µM for EAAT1, EAAT2, and EAAT3, respectively). L-TBOA is the most active isomer of DL-TBOA, as sold by competitors, and approximately twice as potent for inhibition of EAAT1 and EAAT2. 

    EAAT1 EAAT2 EAAT3
    (IC50 μM) (IC50 μM) (IC50 μM)
  dl-TBOA 48 ± 4.1 7.0 ± 1.1 8.0 ± 1.9
  l-TBOA 23 ± 4.4 3.8 ± 1.0 7.0 ± 1.5
  d-TBOA 637 ± 175 64 ± 14 21 ± 2.3


IC50 values of THA derivatives for blocking [14C]glutamate uptake in COS-1 cells expressing EAAT1–3 (data taken from Shimamoto et al.)

Order
Size Unit Price Stock
5 mg €135.00 In Stock
25 mg €475.00 In Stock
Need more? Bulk Inquiry

Related Products

Axon ID Name Description From price
1156 Ifenprodil L-(+)-tartrate NMDA antagonist €55.00
1200 CNQX AMPA/Kainate antagonist €85.00
1201 DNQX AMPA/Kainate antagonist €50.00
1217 CFM 2 AMPA antagonist €115.00
1222 MPEP hydrochloride mGluR5 antagonist €75.00
1224 (±)-LY 367385 mGluR1a antagonist €80.00
1227 WY 14643 PPARα agonist €45.00
1237 GW 7647 PPARα agonist €95.00
1246 Eliprodil NMDA antagonist €90.00
1249 N 20C hydrochloride NMDA antagonist €85.00
1259 Desmethyl YM 298198 hydrochloride mGluR1 antagonist €140.00
1260 YM 298198 hydrochloride mGluR1 antagonist €110.00
1262 Gavestinel NMDA antagonist (glycine site) €110.00
1312 YM 90K hydrochloride AMPA antagonist €85.00
1314 RO 25-6981 hydrochloride NMDA NR2B antagonist €110.00
1345 Fenobam mGluR5 antagonist €70.00
1353 Lamotrigine Glutamate antagonist; Na+ channel blocker €60.00
1374 GYKI 53655 AMPA antagonist €130.00
1406 CP 101606 mesylate NMDA NR2B antagonist €85.00
1425 VU 29 Positive allosteric modulator (PAM) of mGluR5 €100.00
1431 CPPHA Positive allosteric modulator (PAM) of mGluR5 €95.00
1434 RGH 896 NMDA NR2B antagonist €95.00
1466 A 769662 AMPK activator €85.00
1567 KRP 297 PPARα agonist; PPARγ agonist €110.00
1644 Biphenyl-indanone A Positive allosteric modulator (PAM) of mGluR2 €95.00
1739 (RS)-3,5-DHPG mGluR1 and mGluR5 agonist (rac. Axon 1740) €90.00
1740 (S)-3,5-DHPG mGluR1 and mGluR5 agonist €85.00
1747 AZ 12216052 Positive allosteric modulator (PAM) of mGluR8 €110.00
1788 S 18986 Positive allosteric modulator of AMPA receptor €105.00
1795 VU 0360223 mGluR5 antagonist €115.00
1830 VU 0364439 Positive allosteric modulator (PAM) of mGluR4 €115.00
1842 VU 0361737 Positive allosteric modulator (PAM) of mGluR4 €85.00
1894 VU 0357121 Positive allosteric modulator (PAM) of mGluR5 €85.00
1972 CTEP Negative allosteric modulator (NAM) of mGluR5 €120.00
2079 CMPDA Positive allosteric modulator of AMPA receptor €85.00
2114 CP 775146 Potent and selective PPARα agonist €85.00
2155 A 841720 Non-competitive mGluR1 antagonist €85.00
3777 (R)-AS-1 First-in-class highly selective and orally bioavailable PAM of EAAT2 €145.00

The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

Newsletter
Give Feedback
 
Send E-mail

Customer Support

About Axon Medchem

Download Product Catalog

Download the Axon Ligands™ catalogue 2021 Spring Edition

Follow Us

© 2016 Axon Medchem. All Rights Reserved.

Send us a message

×

Contact Us

* Required Fields

Please wait...