TBOA ammonia salt, L- - TBOA | (3S)-3-(Phenylmethoxy)-L-aspartic acid ammonia salt

Based on 12 reference(s) in Google Scholar 9 10 12

Axon 2427

CAS [N.A.]

MF C11H13NO5.NH3
MW 256.26

  • Purity: 99%
  • Optical purity: Optically pure
  • Soluble in water and DMSO

TBOA ammonia salt, L-

Description

Very potent blocker for the human excitatory amino acid transporters (EAAT1–3; IC50 values 23 µM, 3.8 µM, 7.0 µM for EAAT1, EAAT2, and EAAT3, respectively). L-TBOA is the most active isomer of DL-TBOA, as sold by competitors, and approximately twice as potent for inhibition of EAAT1 and EAAT2. 

    EAAT1 EAAT2 EAAT3
    (IC50 μM) (IC50 μM) (IC50 μM)
  dl-TBOA 48 ± 4.1 7.0 ± 1.1 8.0 ± 1.9
  l-TBOA 23 ± 4.4 3.8 ± 1.0 7.0 ± 1.5
  d-TBOA 637 ± 175 64 ± 14 21 ± 2.3


IC50 values of THA derivatives for blocking [14C]glutamate uptake in COS-1 cells expressing EAAT1–3 (data taken from Shimamoto et al.)

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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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