SNS 032 - BMS 387032

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 1614

CAS [345627-80-7]

MF C17H24N4O2S2
MW 380.53

Purity: 99%
Soluble in DMSO

SNS 032

Description

Specific and potent inhibitor of cyclin-dependent kinases (CDK) 2, 7 and 9 (IC50 values to be 38, 4 and 62 nM for cdk2, cdk7 and cdk9 respectively and no activity against 190 additional kinases); SNS 032 induces cell cycle arrest and apoptosis in tumor cell lines

DS Williamson et al. Structure-guided design of pyrazolo[1,5-a]pyrimidines as inhibitors of human cyclin-dependent kinase 2. Bioorg. Med. Chem. Lett. 2005, 15(4), 863-867.

R Chen et al. Mechanism of action of SNS-032, a novel cyclin-dependent kinase inhibitor, in chronic lymphocytic leukemia. Blood, 2009, 113(19), 4637-4645.

WG Tong et al. Phase I and Pharmacologic Study of SNS-032, a Potent and Selective Cdk2, 7, and 9 Inhibitor, in Patients With Advanced Chronic Lymphocytic Leukemia and Multiple Myeloma. J. Clin. Oncol. 2010, 28(18), 3015-3022.

MA Dickson and GK Schwartz. Development of cell-cycle inhibitors for cancer therapy. Curr. Oncol. 2009, 16(2), 36-43.

CDK inhibitor (2, 7 and 9 specific)

Chemical name

N-(5-((5-tert-butyloxazol-2-yl)methylthio)thiazol-2-yl)piperidine-4-carboxamide

Parent CAS No.

[345627-80-7]

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5 mg	€85.00	In Stock
25 mg	€275.00	In Stock

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Size	Unit Price	Stock
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2 x 25 mg	€380.00	In Stock

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SNS 032 - BMS 387032

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SNS 032 - BMS 387032

Description

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