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5-Hydroxy-DPAT hydrobromide
- 5-OH-DPAT
Axon 1006
- Parent CAS: 68593-96-4
Purity:
99%
- Soluble in water and DMSO
- MF: C16H25NO.HBr
- MW: 328.29
Description
5-Hydroxy-DPAT hydrobromide is a potent and selective dopamine D2 receptor agonist. Radiolabeled [11C]5-OH-DPAT has been investigated as a PET ligand for imaging the high-affinity state of dopamine D2/D3 receptors.
D2/D3 receptor agonist ligands are valuable tools for studying dopamine receptor coupling, receptor occupancy and active-state receptor conformations. 5-Hydroxy-DPAT hydrobromide is particularly relevant for dopaminergic neuroimaging and receptor-state pharmacology research.
5-Hydroxy-DPAT hydrobromide is the racemate of the more active (S)-5-Hydroxy-DPAT hydrobromide (Axon 1008), and less active (R)-5-Hydroxy-DPAT hydrobromide (Axon 1007).
Key Features
- Potent and selective dopamine D2 receptor agonist
- DPAT-derived dopaminergic ligand
- Relevant to D2/D3 high-affinity receptor-state studies
- Radiolabeled analogue investigated for PET applications
Applications
- Dopamine D2 receptor pharmacology
- D2/D3 receptor active-state research
- PET radioligand development studies
- Dopaminergic CNS pathway assays
More Information
| Parent CAS No. | 68593-96-4 |
|---|---|
| Chemical Name | 6-Dipropylamino-5,6,7,8-tetrahydro-naphthalen-1-ol hydrobromide |
| SMILES | C1C=C2CC(N(CCC)CCC)CCC2=C(O)C=1.Br |
| MFCD | MFCD10565882 |
| InChi | InChI=1S/C16H25NO.BrH/c1-3-10-17(11-4-2)14-8-9-15-13(12-14)6-5-7-16(15)18;/h5-7,14,18H,3-4,8-12H2,1-2H3;1H |
| InChiKey | QHPNEGRNHVBQOB-UHFFFAOYSA-N |
| CID | 12280577 |
| Short Description | D2 agonist |
References
- A. Karlsson et al. (R)- and (S)-5-hydroxy-2-(dipropylamino)tetralin (5-OH DPAT): Assessment of optical purities and dopaminergic activities. Chirality. 1989-1995, 2(2), 90-95.
- B Shi et al. Radiosynthesis and in vitro evaluation of 2-(N-alkyl-N-1'-11C-propyl)amino-5-hydroxytetralin analogs as high affinity agonists for dopamine D-2 receptors.Nucl Med Biol. 1999, 26(7), 725-35. (PubMed)
- J Mukherjee et al. In vitro and in vivo evaluation of the binding of the dopamine D2 receptor agonist (11)C-(R,S)-5-hydroxy-2-(di-n-propylamino)tetralin in rodents and nonhuman primate.Synapse. 2000, 37(1), 64-70. (PubMed)
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