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NKL 22
- PAOA
- Soluble in DMSO
- MF: C19H23N3O2
- MW: 325.4
Description
NKL 22 is an inhibitor of histone deacetylase with an IC50 value of 78 μM.
More Information
| Parent CAS No. | 537034-15-4 |
|---|---|
| Chemical Name | N1-(2-Aminophenyl)-N7-phenylheptanediamide |
| SMILES | C1C=C(NC(=O)CCCCCC(NC2C(N)=CC=CC=2)=O)C=CC=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C19H23N3O2/c20-16-11-7-8-12-17(16)22-19(24)14-6-2-5-13-18(23)21-15-9-3-1-4-10-15/h1,3-4,7-12H,2,5-6,13-14,20H2,(H,21,23)(H,22,24) |
| InChiKey | ZAIULUYKQLVQFH-UHFFFAOYSA-N |
| CID | 9543539 |
| Short Description | HDAC inhibitor |
References
- JC Wong et al. Structural biasing elements for in-cell histone deacetylase paralog selectivity. J Am Chem Soc. 2003 May 14;125(19):5586-7.
- D Herman et al. Histone deacetylase inhibitors reverse gene silencing in Friedreich's ataxia. Nat Chem Biol. 2006 Oct;2(10):551-8. doi: 10.1038/nchembio815. Epub 2006 Aug 20. Erratum in: Nat Chem Biol. 2007 Jul;3(7):432.
- EA Thomas et al. The HDAC inhibitor 4b ameliorates the disease phenotype and transcriptional abnormalities in Huntington's disease transgenic mice. Proc Natl Acad Sci U S A. 2008 Oct 7;105(40):15564-9.
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