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AR-42
- Optical Purity: Optically pure
- Soluble in DMSO
- MF: C18H20N2O3
- MW: 312.36
Description
AR-42 is a potent histone deacetylase inhibitor with an IC50 value of 16 nM. It induces cell-cycle arrest, apoptosis and microRNA expression changes in pancreatic cancer models and has reported anticancer activity across leukemia, myeloma, prostate, ovarian, glioma and bladder cancer models.
HDAC inhibition alters chromatin accessibility and transcriptional programs that regulate proliferation, survival and differentiation. AR-42 is useful for studying epigenetic anticancer mechanisms and HDAC-dependent transcriptional regulation.
Key Features
- Potent HDAC inhibitor
- IC50: 16 nM
- Induces cell-cycle arrest and apoptosis
- Modulates cancer-associated microRNA expression
Applications
- HDAC pharmacology
- Cancer epigenetics research
- Apoptosis and cell-cycle assays
- Pancreatic cancer and hematologic malignancy models
More Information
| Parent CAS No. | 935881-37-1 |
|---|---|
| Chemical Name | (S)-N-Hydroxy-4-(3-methyl-2-phenylbutanamido)benzamide |
| SMILES | C1C=CC([C@@H](C(NC2C=CC(C(=O)NO)=CC=2)=O)C(C)C)=CC=1 |&1:4,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C18H20N2O3/c1-12(2)16(13-6-4-3-5-7-13)18(22)19-15-10-8-14(9-11-15)17(21)20-23/h3-12,16,23H,1-2H3,(H,19,22)(H,20,21)/t16-/m0/s1 |
| InChiKey | LAMIXXKAWNLXOC-INIZCTEOSA-N |
| CID | 6918848 |
| Short Description | HDAC inhibitor |
References
- Q Lu et al. Structure-based optimization of phenylbutyrate-derived histone deacetylase inhibitors. J Med Chem. 2005 Aug 25;48(17):5530-5.
- YJ Chen et al. Novel histone deacetylase inhibitor AR-42 exhibits antitumor activity in pancreatic cancer cells by affecting multiple biochemical pathways. PLoS One. 2017 Aug 22;12(8):e0183368.
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