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MS 275
- Entinostat - SNDX 275
- Soluble in DMSO
- MF: C21H20N4O3
- MW: 376.41
Description
MS 275 (Entinostat) is a potent and long-lasting class I histone deacetylase (HDAC) inhibitor that inhibits HDAC1 and HDAC3 with reported IC50 values of 0.51 μM and 1.7 μM, respectively.
Class I HDACs regulate chromatin accessibility, transcriptional repression, cell-cycle progression and apoptosis. MS 275 is widely used to study epigenetic regulation and HDAC-dependent responses in oncology and immunology models.
Key Features
- Class I HDAC inhibitor
- Reported IC50: 0.51 μM for HDAC1 and 1.7 μM for HDAC3
- Modulates histone acetylation and transcriptional regulation
- Long-lasting epigenetic research tool
Applications
- HDAC1 and HDAC3 pharmacology
- Histone acetylation and chromatin regulation studies
- Cancer cell differentiation and apoptosis assays
- Epigenetic therapy and combination-treatment research
More Information
| Parent CAS No. | 209783-80-2 |
|---|---|
| Chemical Name | pyridin-3-ylmethyl 4-(2-aminophenylcarbamoyl)benzylcarbamate |
| SMILES | C(OCC1=CC=CN=C1)(=O)NCC1=CC=C(C(NC2=CC=CC=C2N)=O)C=C1 |
| MFCD | MFCD08272435 |
| InChi | InChI=1S/C21H20N4O3/c22-18-5-1-2-6-19(18)25-20(26)17-9-7-15(8-10-17)13-24-21(27)28-14-16-4-3-11-23-12-16/h1-12H,13-14,22H2,(H,24,27)(H,25,26) |
| InChiKey | INVTYAOGFAGBOE-UHFFFAOYSA-N |
| CID | 4261 |
| Short Description | HDAC inhibitor |
References
- A Saito et al. A synthetic inhibitor of histone deacetylase, MS-275, with marked in vivo antitumor activity against human tumors. Proc. Natl. Acad. Sci. USA 1999, 96, 4592-4597.
- M. V. Simonini et al. The benzamide MS-275 is a potent, long-lasting brain region-selective inhibitor of histone deacetylases. Proc. Natl. Acad. Sci. USA 2006, 103(5), 1587-1592.
- IY Eyüpoglu et al. Experimental therapy of malignant gliomas using the inhibitor of histone deacetylase MS-275. Mol. Cancer Ther. 2006, 5, 1248-1255.
- HS Lin et al. Anti-rheumatic activities of histone deacetylase (HDAC) inhibitors in vivo in collagen-induced arthritis in rodents. Br. J. Pharmacol. 2007, 150, 862-872.
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