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RGFP 966
- Soluble in DMSO
- MF: C21H19FN4O
- MW: 362.4
Description
RGFP 966 is a selective HDAC3 inhibitor with a reported IC50 value of 0.08 µM and no detectable affinity for other HDACs at concentrations up to 15 µM in the cited profiling. It enhances long-term object memory acquisition and facilitates extinction of cocaine-seeking behavior in mouse studies.
HDAC3 regulates transcriptional repression, synaptic plasticity, memory consolidation and addiction-related gene expression. RGFP 966 is relevant for selective epigenetic modulation in neurobiology and behavioral pharmacology.
Key Features
- Selective HDAC3 inhibitor
- Minimal activity against other HDACs in reported profiling
- Enhances long-term object memory acquisition
- Facilitates extinction of cocaine-seeking behavior
Applications
- HDAC3 activity assays
- Epigenetic neurobiology research
- Learning and memory studies
- Addiction and behavioral extinction models
More Information
| Parent CAS No. | 1357389-11-7 |
|---|---|
| Chemical Name | (E)-N-(2-amino-4-fluorophenyl)-3-(1-cinnamyl-1H-pyrazol-4-yl)acrylamide |
| SMILES | C(NC1=CC=C(F)C=C1N)(=O)/C=C/C1=CN(C/C=C/C2=CC=CC=C2)N=C1 |
| MFCD | N.A. |
| InChi | InChI=1S/C21H19FN4O/c22-18-9-10-20(19(23)13-18)25-21(27)11-8-17-14-24-26(15-17)12-4-7-16-5-2-1-3-6-16/h1-11,13-15H,12,23H2,(H,25,27)/b7-4+,11-8+ |
| InChiKey | BLVQHYHDYFTPDV-VCABWLAWSA-N |
| CID | 56650312 |
| Short Description | HDAC3 inhibitor |
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