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ACY-241
- Citarinostat
- Soluble in DMSO
- MF: C24H26ClN5O3
- MW: 467.95
Description
ACY-241 is a selective, orally available histone deacetylase (HDAC) 6 inhibitor with an IC50 value of 2.6 nM.
More Information
| Parent CAS No. | 1316215-12-9 |
|---|---|
| Chemical Name | 2-((2-Chlorophenyl)(phenyl)amino)-N-(7-(hydroxyamino)-7-oxoheptyl)pyrimidine-5-carboxamide |
| SMILES | C1C=CC(N(C2C=CC=CC=2)C2N=CC(C(=O)NCCCCCCC(=O)NO)=CN=2)=C(Cl)C=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C24H26ClN5O3/c25-20-12-7-8-13-21(20)30(19-10-4-3-5-11-19)24-27-16-18(17-28-24)23(32)26-15-9-2-1-6-14-22(31)29-33/h3-5,7-8,10-13,16-17,33H,1-2,6,9,14-15H2,(H,26,32)(H,29,31) |
| InChiKey | VLIUIBXPEDFJRF-UHFFFAOYSA-N |
| CID | 53340426 |
| Short Description | HDAC6 inhibitor |
References
- P Huang et al. Selective HDAC inhibition by ACY-241 enhances the activity of paclitaxel in solid tumor models. Oncotarget. 2017 Jan 10;8(2):2694-2707.
- J Bae et al. Histone deacetylase (HDAC) inhibitor ACY241 enhances anti-tumor activities of antigen-specific central memory cytotoxic T lymphocytes against multiple myeloma and solid tumors. Leukemia. 2018 Sep;32(9):1932-1947.
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