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UF 010
- Soluble in DMSO and EtOH
- MF: C11H15BrN2O
- MW: 271.15
Description
Class I selective HDAC inhibitor (IC50 values 0.5 μM, 0.1 μM, 0.06 μM, and 1.5 μM for HDAC1, HDAC2, HDAC3, and HDAC8 respectively) that inhibits cancer cell proliferation. Consistently induced the accumulation of acetylated histones (H2B, H3, and H4 but no effect on H2A) and p53 in vitro, without affecting α-tubulin.
More Information
| Parent CAS No. | 537672-41-6 |
|---|---|
| Chemical Name | 4-bromo-N'-butylbenzohydrazide |
| SMILES | C(NNCCCC)(=O)C1=CC=C(Br)C=C1 |
| MFCD | N.A. |
| InChi | InChI=1S/C11H15BrN2O/c1-2-3-8-13-14-11(15)9-4-6-10(12)7-5-9/h4-7,13H,2-3,8H2,1H3,(H,14,15) |
| InChiKey | BVQCFCYPFJOOAV-UHFFFAOYSA-N |
| CID | 4596836 |
| Short Description | HDAC inhibitor |
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