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CI 994
- PD123654 - Tacedinaline
- Soluble in DMSO
- MF: C15H15N3O2
- MW: 269.3
Description
CI 994 (Tacedinaline, PD123654) is an orally bioavailable histone deacetylase (HDAC) inhibitor that inhibits HDAC1 and HDAC2 and induces histone hyperacetylation in living cells. It promotes G1 cell-cycle arrest, antiproliferative effects and apoptosis in reported models.
HDAC1/2 regulate chromatin accessibility, transcriptional repression and cancer-cell survival programs. CI 994 is useful for studying class I HDAC pharmacology, epigenetic modulation and tumor cell response to histone deacetylase inhibition.
Key Features
- Orally bioavailable HDAC inhibitor
- Targets HDAC1 and HDAC2
- Induces histone hyperacetylation
- Promotes cell-cycle arrest and apoptosis in reported models
Applications
- HDAC enzyme assays
- Histone acetylation studies
- Epigenetic oncology research
- Cancer cell-cycle and apoptosis assays
More Information
| Parent CAS No. | 112522-64-2 |
|---|---|
| Chemical Name | 4-acetamido-N-(2-aminophenyl)benzamide |
| extra_info | . |
| SMILES | C(NC1=CC=CC=C1N)(=O)C1=CC=C(NC(C)=O)C=C1 |
| MFCD | MFCD00866266 |
| InChi | InChI=1S/C15H15N3O2/c1-10(19)17-12-8-6-11(7-9-12)15(20)18-14-5-3-2-4-13(14)16/h2-9H,16H2,1H3,(H,17,19)(H,18,20) |
| InChiKey | VAZAPHZUAVEOMC-UHFFFAOYSA-N |
| CID | 2746 |
| Short Description | HDAC inhibitor |
References
- AG Kraker et al. Modulation of histone acetylation by [4-(acetylamino)-N-(2-amino-phenyl) benzamide] in HCT-8 colon carcinoma. Mol. Cancer Ther. 2003, (4), 401-408.
- M Loprevite et al. In Vitro Study of CI-994, a Histone Deacetylase Inhibitor, in Non-Small Cell Lung Cancer Cell Lines. Oncol. Res. Feat. Preclin. Clin. Cancer Ther. 2005, 15(1), 39-48.
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