Bulk Inquiry
BRD 73954
- Soluble in DMSO
- MF: C16H16N2O3
- MW: 284.31
Description
First dual HDAC 6/8 inhibitor (IC50 values 9000 nM, >33000 nM, 36 nM, and 120 nM for HDAC2, 4, 6, and 8. respectively) with excellent selectivity over the other class I and II HDACs tested (75- and 130-fold less potent for the next closest isoforms). Simultaneous inhibition of HDAC6 and HDAC8 has many potential therapeutic applications, providing a larger therapeutic window than inhibition of HDAC1–3.
More Information
| Parent CAS No. | 1440209-96-0 |
|---|---|
| Chemical Name | N1-hydroxy-N3-phenethylisophthalamide |
| SMILES | C1(C(NO)=O)=CC=CC(C(NCCC2=CC=CC=C2)=O)=C1 |
| MFCD | N.A. |
| InChi | InChI=1S/C16H16N2O3/c19-15(17-10-9-12-5-2-1-3-6-12)13-7-4-8-14(11-13)16(20)18-21/h1-8,11,21H,9-10H2,(H,17,19)(H,18,20) |
| InChiKey | FIHKWEQJEDRIFS-UHFFFAOYSA-N |
| CID | 71680913 |
| Short Description | Dual HDAC 6/8 inhibitor |
Related Products
| AXON ID | NAME | FROM PRICE |
|---|---|---|
| 4468 | Colrestat |
From $154.00 |
| 1548 | LBH 589 |
From $99.00 |
| 1645 | HDAC6 inhibitor ISOX |
From $121.00 |
| 1707 | MC 1568 |
From $93.50 |
| 1777 | SB 939 |
From $104.50 |
| 1801 | Pyroxamide |
From $99.00 |
| 1803 | MS 275 |
From $66.00 |
| 1853 | PCI 34051 |
From $99.00 |
| 2004 | Tubastatin A hydrochloride |
From $104.50 |
| 2014 | CI 994 |
From $77.00 |
| 2180 | TMP 195 |
From $121.00 |
| 2195 | RGFP 966 |
From $93.50 |
| 2209 | Sodium butyrate |
From $55.00 |
| 2359 | Nexturastat A |
From $99.00 |
| 2394 | AR-42 |
From $137.50 |
| 2893 | Tucidinostat |
From $104.50 |
| 2996 | TH 34 |
From $132.00 |
| 3038 | CXD101 |
From $137.50 |
| 3039 | ACY-241 |
From $132.00 |
| 3114 | Vorinostat |
From $49.50 |
| 3115 | Belinostat |
From $77.00 |
| 3397 | BG45 |
From $88.00 |
| 3399 | BML-210 |
From $88.00 |
| 3409 | NKL 22 |
From $88.00 |
