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SB 939
- Pracinostat
- Soluble in DMSO
- MF: C20H30N4O2
- MW: 358.48
Description
SB 939 is a potent orally active histone deacetylase (HDAC) inhibitor active against class I, II and IV HDAC enzymes.
HDAC inhibition alters chromatin accessibility, transcription, differentiation and apoptosis. SB 939 (Pracinostat) is useful for studying broad HDAC pathway inhibition and antiproliferative responses in cancer models.
Key Features
- Orally active HDAC inhibitor
- Targets class I, II and IV HDACs
- Induces epigenetic transcriptional modulation
- Reported antiproliferative activity across tumor cell lines
Applications
- HDAC enzyme assays
- Epigenetic and chromatin biology studies
- Cancer cell proliferation and apoptosis models
- Combination epigenetic therapy research
More Information
| Parent CAS No. | 929016-96-6 |
|---|---|
| Chemical Name | (E)-3-(2-butyl-1-(2-(diethylamino)ethyl)-1H-benzo[d]imidazol-5-yl)-N-hydroxyacrylamide |
| SMILES | C(NO)(=O)/C=C/C1=CC=C2N(CCN(CC)CC)C(CCCC)=NC2=C1 |
| MFCD | MFCD17215206 |
| InChi | InChI=1S/C20H30N4O2/c1-4-7-8-19-21-17-15-16(10-12-20(25)22-26)9-11-18(17)24(19)14-13-23(5-2)6-3/h9-12,15,26H,4-8,13-14H2,1-3H3,(H,22,25)/b12-10+ |
| InChiKey | JHDKZFFAIZKUCU-ZRDIBKRKSA-N |
| CID | 49855250 |
| Short Description | HDAC inhibitor |
References
- V Novotny-Diermary et al. SB939, a novel potent and orally active histone deacetylase inhibitor with high tumor exposure and efficacy in mouse models of colorectal cancer. Mol. Cancer Ther. 2010, 9(3), 642-652.
- V Novotny-Diermary et al. Pharmacodynamic evaluation of the target efficacy of SB939, an oral HDAC inhibitor with selectivity for tumor tissue. Mol. Cancer Ther. 2011, 10(7), 1207-1217.
- AR Razak et al. Phase I clinical, pharmacokinetic and pharmacodynamic study of SB939, an oral histone deacetylase (HDAC) inhibitor, in patients with advanced solid tumours. Br. J. Cancer. 2011, 104(5), 756-762.
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