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TMP 195
- TFMO 2
- Soluble in DMSO
- MF: C23H19F3N4O3
- MW: 456.42
Description
Selective and cell-active class IIa histone deacetylase (HDAC) inhibitor, with IC50 values of 111, 106, 46, 9 nM for HDAC4, HDAC5, HDAC7 and HDAC9 respectively; >100 fold more selective vs other HDACs (IC50: >10 μM).The trifluoromethyloxadiazole (TFMO) moiety in TMP 195 as a new metal binding group circumvents the selectivity and pharmacologic liabilities of hydroxamates groups used in other metalloenzyme inhibitors. TMP 195 has a restraint impact on gene expression, and lacks overt cytotoxicity.
More Information
| Parent CAS No. | 1314891-22-9 |
|---|---|
| Chemical Name | N-(2-methyl-2-(2-phenyloxazol-4-yl)propyl)-3-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzamide |
| SMILES | C1(C(=O)NCC(C)(C)C2N=C(C3C=CC=CC=3)OC=2)C=C(C2=NOC(C(F)(F)F)=N2)C=CC=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C23H19F3N4O3/c1-22(2,17-12-32-20(28-17)14-7-4-3-5-8-14)13-27-19(31)16-10-6-9-15(11-16)18-29-21(33-30-18)23(24,25)26/h3-12H,13H2,1-2H3,(H,27,31) |
| InChiKey | QTCSXAUJBQZZSN-UHFFFAOYSA-N |
| CID | 67324851 |
| Short Description | IIa HDAC inhibitor |
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