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MC 1568
- Soluble in DMSO
- MF: C17H15FN2O3
- MW: 314.31
Description
MC 1568 is a potent and selective class IIa histone deacetylase (HDAC) inhibitor with activity toward HDAC4, HDAC5 and HDAC7.
Class IIa HDACs regulate chromatin-dependent transcription, differentiation and tissue-specific signaling pathways. MC 1568 is used to separate class IIa HDAC biology from broader pan-HDAC inhibition.
Key Features
- Selective inhibitor of class IIa HDACs
- Targets HDAC4, HDAC5 and HDAC7 biology
- Epigenetic modulator of transcriptional programs
- Useful alternative to pan-HDAC inhibition
Applications
- Class IIa HDAC pathway studies
- Chromatin and transcriptional regulation assays
- Differentiation and developmental models
- Epigenetic inhibitor selectivity profiling
More Information
| Parent CAS No. | 852475-26-4 |
|---|---|
| Chemical Name | (E)-3-(4-((E)-3-(3-fluorophenyl)-3-oxoprop-1-enyl)-1-methyl-1H-pyrrol-2-yl)-N-hydroxyacrylamide |
| SMILES | ONC(/C=C/C1=CC(/C=C/C(=O)C2C=CC=C(F)C=2)=CN1C)=O |
| MFCD | MFCD16875423 |
| InChi | InChI=1S/C17H15FN2O3/c1-20-11-12(9-15(20)6-8-17(22)19-23)5-7-16(21)13-3-2-4-14(18)10-13/h2-11,23H,1H3,(H,19,22)/b7-5+,8-6+ |
| InChiKey | QRDAPCMJAOQZSU-KQQUZDAGSA-N |
| CID | 11381449 |
| Short Description | IIa HDAC inhibitor |
References
- V Duong et al. Specific activity of class II histone deacetylases in human breast cancer cells. Mol. Cancer Res. 2008, 6(12), 1908–1919.
- A Nebbioso et al. Selective class II HDAC inhibitors impair myogenesis by modulating the stability and activity of HDAC–MEF2 complexes. EMBO Rep. 2009, 10(7), 776-782.
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