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Colrestat
- Soluble in DMSO
- MF: C24H21N3O4
- MW: 415.44
Description
Colrestat is a highly potent and selective class I histone deacetylase (HDAC) inhibitor with IC50 values of 41.2 nM, 52.5 nM, and 74.3 nM for HDAC1, HDAC2, and HDAC3, respectively. Colrestat induced H3K9 acetylation, p21 upregulation, and G2/M arrest.
Key Features
- Potent and selective class I HDAC inhibitor
- IC50: 41.2 nM (HDAC1), 52.5 nM (HDAC2), and 74.3 nM (HDAC3)
- Induces H3K9 histone acetylation
- Upregulates p21 expression
- Promotes G2/M cell cycle arrest
Applications
- HDAC1, HDAC2, and HDAC3 research
- Epigenetics and chromatin regulation studies
- Histone acetylation investigations
- Cancer biology and oncology research
- Cell cycle regulation and apoptosis studies
More Information
| Parent CAS No. | 3124773-51-6 |
|---|---|
| Chemical Name | N-((4-(N-2-Aminophenylcarbamoyl)phenyl)methyl)-(E)-3-(2H-1,3-benzodioxol-5-yl)acrylamide |
| SMILES | C1=C(/C=C/C(=O)NCC2=CC=C(C(=O)NC3=C(N)C=CC=C3)C=C2)C=CC2OCOC1=2 |
| InChi | InChI=1S/C24H21N3O4/c25-19-3-1-2-4-20(19)27-24(29)18-9-5-17(6-10-18)14-26-23(28)12-8-16-7-11-21-22(13-16)31-15-30-21/h1-13H,14-15,25H2,(H,26,28)(H,27,29)/b12-8+ |
| InChiKey | QRQCTUOLOHTZAD-XYOKQWHBSA-N |
| Short Description | HDAC1/2/3 inhibitor |
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