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CKI-7 dihydrochloride
- Parent CAS: 120615-25-0
- Soluble in water and DMSO
- MF: C11H14Cl3N3O2S
- MW: 358.67
Description
CKI-7 dihydrochloride is a selective casein kinase I inhibitor with an IC50 value of 6 μM. CKI-7 dihydrochloride inhibits SGK as potently as CK1, and several other kinases, such as ribosomal S6 kinase-1 (S6K1) and mitogen- and stress-activated protein kinase-1 (MSK1).
More Information
| Parent CAS No. | 120615-25-0 |
|---|---|
| Chemical Name | N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulfonamide dihydrochloride |
| SMILES | C1C2C(Cl)=CC=C(S(=O)(=O)NCCN)C=2C=NC=1.Cl.Cl |
| MFCD | MFCD00897689 |
| InChi | InChI=1S/C11H12ClN3O2S.2ClH/c12-10-1-2-11(18(16,17)15-6-4-13)9-7-14-5-3-8(9)10;;/h1-3,5,7,15H,4,6,13H2;2*1H |
| InChiKey | JUAVTXYOCISSSL-UHFFFAOYSA-N |
| CID | 16078955 |
| Short Description | CK1 inhibitor |
References
- T Chijiwa et al. A newly synthesized selective casein kinase I inhibitor, N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide, and affinity purification of casein kinase I from bovine testis. J Biol Chem. 1989 Mar 25;264(9):4924-7.
- G Rena et al. D4476, a cell-permeant inhibitor of CK1, suppresses the site-specific phosphorylation and nuclear exclusion of FOXO1a. EMBO Rep. 2004 Jan;5(1):60-5.
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