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APIO-EE-07
Axon 3328
CAS:
1606160-46-6
Purity:
98%
- Soluble in DMSO
- MF: C18H11FN2O4
- MW: 338.29
Description
APIO-EE-07 is a dual-target inhibitor of RSK1 and MSK2. APIO-EE-07 inhibited cell growth and induced apoptosis and also increased expression of Bax as well as cleaved caspase-3 and -PARP in colon cancer cells by downregulating RSK1 and MSK2 downstream targets, including CREB and ATF1.
More Information
| Parent CAS No. | 1606160-46-6 |
|---|---|
| Chemical Name | 5-Fluoro-3-(4-(4-nitrophenyl)-2-oxobut-3-enylidene)indolin-2-one |
| SMILES | C1C=C(/C=C/C(=O)/C=C2C3C=C(F)C=CC=3NC2=O)C=CC=1[N+]([O-])=O |
| MFCD | N.A. |
| InChi | InChI=1S/C18H11FN2O4/c19-12-4-8-17-15(9-12)16(18(23)20-17)10-14(22)7-3-11-1-5-13(6-2-11)21(24)25/h1-10H,(H,20,23)/b7-3+,16-10+ |
| InChiKey | MHGVFCIOFWQTHT-VVNOOFQYSA-N |
| CID | 74221214 |
| Short Description | RSK1/MSK2 inhibitor |
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