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LJI308
Axon 3991
CAS:
1627709-94-7
Purity:
99%
- Soluble in DMSO and EtOH
- MF: C21H18F2N2O2
- MW: 368.38
Description
LJI308 is a potent and specific pan-RSK inhibitor with IC50 values of 6 nM, 4 nM and 13 nM for RSK1, RSK2 and RSK3, respectively.
More Information
| Parent CAS No. | 1627709-94-7 |
|---|---|
| Chemical Name | 2,6-Difluoro-4-(4-(4-morpholinophenyl)pyridin-3-yl)phenol |
| SMILES | C1(F)C(O)=C(F)C=C(C2C(C3C=CC(N4CCOCC4)=CC=3)=CC=NC=2)C=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C21H18F2N2O2/c22-19-11-15(12-20(23)21(19)26)18-13-24-6-5-17(18)14-1-3-16(4-2-14)25-7-9-27-10-8-25/h1-6,11-13,26H,7-10H2 |
| InChiKey | YUYJEQHNWKQNBT-UHFFFAOYSA-N |
| CID | 118704762 |
| Short Description | RSK inhibitor |
References
- R Jain et al. Discovery of Potent and Selective RSK Inhibitors as Biological Probes. J Med Chem. 2015 Sep 10;58(17):6766-83.
- I Aronchik et al. Novel potent and selective inhibitors of p90 ribosomal S6 kinase reveal the heterogeneity of RSK function in MAPK-driven cancers. Mol Cancer Res. 2014 May;12(5):803-12.
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