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Belinostat
- PXD101
- Soluble in 0.1N NaOH(aq) and DMSO
- MF: C15H14N2O4S
- MW: 318.35
Description
Belinostat is an inhibitor of histone deacetylase activity that inhibits histone deacetylase activity in HeLa cell extracts with an IC50 value of 27 nM and induces a concentration-dependent (0.2–5 μM) increase in acetylation of histone H4 in tumor cell lines. Belinostat is cytotoxic in vitro in a number of tumor cell lines with IC50 values in the range 0.2–3.4 μM as determined by a clonogenic assay and induces apoptosis.
More Information
| Parent CAS No. | 866323-14-0 |
|---|---|
| Chemical Name | (E)-N-Hydroxy-3-(3-(N-phenylsulfamoyl)phenyl)acrylamide |
| SMILES | C(NO)(=O)/C=C/C1=CC=CC(S(NC2C=CC=CC=2)(=O)=O)=C1 |
| MFCD | N.A. |
| InChi | InChI=1S/C15H14N2O4S/c18-15(16-19)10-9-12-5-4-8-14(11-12)22(20,21)17-13-6-2-1-3-7-13/h1-11,17,19H,(H,16,18)/b10-9+ |
| InChiKey | NCNRHFGMJRPRSK-MDZDMXLPSA-N |
| CID | 6918638 |
| Short Description | HDAC inhibitor |
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