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Vorinostat
- SAHA - Suberanilohydroxamic acid - MK-0683
- Soluble in DMSO
- MF: C14H20N2O3
- MW: 264.32
Description
Vorinostat is an histone deacetylase (HDAC) inhibitor.
More Information
| Parent CAS No. | 149647-78-9 |
|---|---|
| Chemical Name | N1-Hydroxy-N8-phenyloctanediamide |
| SMILES | C1C=C(NC(=O)CCCCCCC(=O)NO)C=CC=1 |
| MFCD | MFCD00945317 |
| InChi | InChI=1S/C14H20N2O3/c17-13(15-12-8-4-3-5-9-12)10-6-1-2-7-11-14(18)16-19/h3-5,8-9,19H,1-2,6-7,10-11H2,(H,15,17)(H,16,18) |
| InChiKey | WAEXFXRVDQXREF-UHFFFAOYSA-N |
| CID | 5311 |
| Short Description | HDAC inhibitor |
References
- JC Stowell et al. The synthesis of N-hydroxy-N'-phenyloctanediamide and its inhibitory effect on proliferation of AXC rat prostate cancer cells. J Med Chem. 1995 Apr 14;38(8):1411-3.
- CL Andersen et al. A phase II study of vorinostat (MK-0683) in patients with primary myelofibrosis and post-polycythemia vera myelofibrosis. Haematologica. 2014;99(1):e5-e7.
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