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Tucidinostat
- Chidamide - HBI-8000 - CS 055 - Epidaza
- Soluble in 0.1N HCl(aq) and DMSO
- MF: C22H19FN4O2
- MW: 390.41
Description
Tucidinostat (Chidamide) is an orally bioavailable inhibitor of HDAC1, HDAC2, HDAC3, and HDAC10 with IC50 values of 0.095, 0.160, 0.067, 0.078 µM, respectively. Tucidinostat exhibits a significant and broad spectrum in vitro and in vivo antitumor activity, including a wide therapeutic index.
More Information
| Parent CAS No. | 1616493-44-7 |
|---|---|
| Chemical Name | (E)-N-(2-Amino-4-fluorophenyl)-4-((3-(pyridin-3-yl)acrylamido)methyl)benzamide |
| SMILES | C1C=C(/C=C/C(=O)NCC2C=CC(C(=O)NC3C(N)=CC(F)=CC=3)=CC=2)C=NC=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C22H19FN4O2/c23-18-8-9-20(19(24)12-18)27-22(29)17-6-3-16(4-7-17)14-26-21(28)10-5-15-2-1-11-25-13-15/h1-13H,14,24H2,(H,26,28)(H,27,29)/b10-5+ |
| InChiKey | SZMJVTADHFNAIS-BJMVGYQFSA-N |
| CID | 12136798 |
| Short Description | HDAC inhibitor |
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