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U 0126
- U 126
- Soluble in DMSO and EtOH
- MF: C18H16N6S2
- MW: 380.49
Description
Non-competitive inhibitior of the dual specificity kinase MEK (IC50 values 0.07 μM and 0.06 μM for MEK1 and MEK2, respectively) that protects the brain against damage resulting from ischemic stroke in mice. U0126 is frequently used in combination with PD 98059 (Axon 1223), and both are found to accelerate differentiation of murine RAW264.7 cells into osteoclast-like cells.
More Information
| Parent CAS No. | 109511-58-2 |
|---|---|
| Chemical Name | 2,3-bis(amino(2-aminophenylthio)methylene)succinonitrile |
| SMILES | C(#N)/C(=C(/N)SC1=CC=CC=C1N)/C(=C(N)/SC1=CC=CC=C1N)/C#N |
| MFCD | MFCD25977152 |
| InChi | InChI=1S/C18H16N6S2/c19-9-11(17(23)25-15-7-3-1-5-13(15)21)12(10-20)18(24)26-16-8-4-2-6-14(16)22/h1-8H,21-24H2/b17-11+,18-12+ |
| InChiKey | DVEXZJFMOKTQEZ-JYFOCSDGSA-N |
| CID | 3006531 |
| Short Description | MEK1/2 inhibitor |
References
- J.V. Duncia et al. MEK inhibitors: the chemistry and biological activity of U0126, its analogs, and cyclization products. Bioorg Med Chem Lett. 1998 Oct 20;8(20):2839-44.
- H. Hotokezaka et al. U0126 and PD98059, specific inhibitors of MEK, accelerate differentiation of RAW264.7 cells into osteoclast-like cells. J Biol Chem. 2002 Dec 6;277(49):47366-72.
- M.F. Favata et al. Identification of a novel inhibitor of mitogen-activated protein kinase kinase. J Biol Chem. 1998 Jul 17;273(29):18623-32.
- S. Namura et al. Intravenous administration of MEK inhibitor U0126 affords brain protection against forebrain ischemia and focal cerebral ischemia. Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11569-74.
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