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Santacruzamate A
- CAY 10683
- Soluble in DMSO
- MF: C15H22N2O3
- MW: 278.35
Description
Santacruzamate A is a potent inhibitor of class I histone deacetylase HDAC2 with weaker activity at HDAC6 and limited activity at HDAC4. It is a marine natural product-derived epigenetic probe with cytotoxic activity in cancer models.
HDAC2 regulates chromatin accessibility and transcriptional programs controlling proliferation, differentiation and survival. Santacruzamate A is useful for studying HDAC2-selective inhibition and class I HDAC-dependent cancer cell responses.
Key Features
- Potent HDAC2 inhibitor
- Reported IC50: 0.11 nM for HDAC2
- Weak activity at HDAC6 and minimal activity at HDAC4 in reported assays
- Epigenetic probe with reported cytotoxic activity
Applications
- HDAC2 pharmacology
- Epigenetic transcription regulation studies
- Cancer cell cytotoxicity assays
- Class I HDAC selectivity profiling
More Information
| Parent CAS No. | 1477949-42-0 |
|---|---|
| Chemical Name | ethyl 4-oxo-4-(phenethylamino)butylcarbamate |
| SMILES | C(OCC)(=O)NCCCC(=O)NCCC1=CC=CC=C1 |
| MFCD | N.A. |
| InChi | InChI=1S/C15H22N2O3/c1-2-20-15(19)17-11-6-9-14(18)16-12-10-13-7-4-3-5-8-13/h3-5,7-8H,2,6,9-12H2,1H3,(H,16,18)(H,17,19) |
| InChiKey | HTOYBIILVCHURC-UHFFFAOYSA-N |
| CID | 72946782 |
| Short Description | HDAC inhibitor |
References
- C.M. Pavlik et al. Santacruzamate A, a potent and selective histone deacetylase inhibitor from the Panamanian marine cyanobacterium cf. Symploca sp. J Nat Prod. 2013 Nov 22;76(11):2026-33.
- Q. Liu et al. Synthesis and biological evaluation of santacruzamate A and analogs as potential anticancer agents. RSC Adv. 2015,5, 1109-1112.
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