Potent inhibitor of erastin-induced ferroptosis, an iron dependent form of cell death morphologically, biochemically and genetically distinct from apoptosis, various forms of necrosis, and autophagy (EC50 value 60 nM in HT-1080 cells). Ferrostatin-1 specifically inhibits cell death induced by RAS-selective lethal compounds (RSLs), but not cell death induced by other oxidative lethal compounds and apoptosis-inducing agents. Ferrostatin-1 does not inhibit ERK phosphorylation or arrest the proliferation of HT-1080 cells, nor does it chelate iron or inhibit protein synthesis. It is capable of blocking the cytotoxic effects of Sorafenib (Axon 1397) in HCC cells.
KEYWORDS: Ferrostatin 1 | supplier | Ferroptosis inhibitor | Fer1 |CAS[347174-05-4] |RAS proteins | Inhibitor | Apoptosis | ROS | RAS-related | nonapoptotic | RSL | Erastin induced | oxidative | cell death | cancer |Huntington's | HD | PUFA | Sorafenib