Ferrostatin 1 - Fer-1

Based on 18 reference(s) in Google Scholar 9 10 18

Axon 2293

CAS [347174-05-4]

MF C15H22N2O2
MW 262,35

  • Purity: 99%
  • Soluble in DMSO

Ferrostatin 1

Description

Potent inhibitor of erastin-induced ferroptosis, an iron dependent form of cell death morphologically, biochemically and genetically distinct from apoptosis, various forms of necrosis, and autophagy (EC50 value 60 nM in HT-1080 cells). Ferrostatin-1 specifically inhibits cell death induced by RAS-selective lethal compounds (RSLs), but not cell death induced by other oxidative lethal compounds and apoptosis-inducing agents. Ferrostatin-1 does not inhibit ERK phosphorylation or arrest the proliferation of HT-1080 cells, nor does it chelate iron or inhibit protein synthesis. It is capable of blocking the cytotoxic effects of Sorafenib (Axon 1397) in HCC cells.

KEYWORDS: Ferrostatin 1 | supplier | Ferroptosis inhibitor | Fer1 |CAS[347174-05-4] |RAS proteins | Inhibitor | Apoptosis | ROS | RAS-related | nonapoptotic | RSL | Erastin induced | oxidative | cell death | cancer |Huntington's | HD | PUFA | Sorafenib

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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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