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IWP L6
- Soluble in DMSO
- MF: C25H20N4O2S2
- MW: 472.58
Description
IWP-L6 is a highly potent Porcupine (Porcn) inhibitor with an EC50 value of 0.5 nM. Porcn is a membrane-bound O-acyltransferase (MBOAT) that is essential for Wnt ligand palmitoylation, secretion, and signaling. IWP-L6 acts as a potent Wnt signaling inhibitor and is approximately 60-fold more potent than IWP-2 (Axon 4370).
Wnt signaling plays a critical role in embryonic development, stem cell maintenance, tissue regeneration, organogenesis, and cell fate determination. IWP-L6 specifically and reversibly blocks Wnt signaling and Wnt-mediated branching morphogenesis in cultured mouse embryonic kidneys. In vivo, IWP-L6 inhibits posterior axis formation and tailfin regeneration in juvenile zebrafish at low micromolar concentrations. IWP-L6 is widely used in stem cell differentiation protocols, organoid culture systems, and developmental biology studies where precise temporal control of Wnt signaling is required. The compound is stable in human plasma for at least 24 hours, making it a valuable tool for stem cell, developmental biology, and regenerative medicine research.
Key Features
- Highly potent Porcn inhibitor
- EC50: 0.5 nM
- Approximately 60-fold more potent than IWP-2
- Blocks Wnt ligand secretion and signaling
- Stable in human plasma for at least 24 hours
Applications
- Wnt signaling research
- Stem cell differentiation and pluripotency studies
- Organoid culture and developmental biology research
- Organogenesis and branching morphogenesis investigations
- Regenerative medicine and tissue regeneration studies
More Information
| Parent CAS No. | 1427782-89-5 |
|---|---|
| Chemical Name | 2-(4-oxo-3-phenyl-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-ylthio)-N-(5-phenylpyridin-2-yl)acetamide |
| SMILES | C(NC1=NC=C(C2=CC=CC=C2)C=C1)(=O)CSC1N(C2=CC=CC=C2)C(=O)C2SCCC=2N=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C25H20N4O2S2/c30-22(28-21-12-11-18(15-26-21)17-7-3-1-4-8-17)16-33-25-27-20-13-14-32-23(20)24(31)29(25)19-9-5-2-6-10-19/h1-12,15H,13-14,16H2,(H,26,28,30) |
| InChiKey | QESQGTFWEQMCMH-UHFFFAOYSA-N |
| CID | 71601111 |
| Short Description | Porcn inhibitor |
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