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PRI-724
- Foscenvivint
- Optical Purity: 0.99
- Soluble in DMSO
- MF: C33H35N6O7P
- MW: 658.64
Description
PRI-724 is the second-generation, potent and specific inhibitor of CBP/β-Catenin complex, and a modulator of the β-Catenin dependent canonical Wnt signaling pathway in cancer stem cells. PRI-724 is a pro-drug, from which the active form C-82 (Axon 3748) is rapidly generated in vivo.
More Information
| Parent CAS No. | 1422253-38-0 |
|---|---|
| Chemical Name | 4-(((6S,9S,9aS)-1-(Benzylcarbamoyl)-2,9-dimethyl-4,7-dioxo-8-(quinolin-8-ylmethyl)octahydro-1H-pyrazino[2,1-c][1,2,4]triazin-6-yl)methyl)phenyl dihydrogen phosphate |
| extra_info | Sold in collaboration with Chemietek |
| SMILES | N1(CC2C=CC=C3C=CC=NC=23)[C@@H](C)[C@]2([H])N(C(=O)NCC3C=CC=CC=3)N(C)CC(=O)N2[C@@H](CC2C=CC(OP(O)(O)=O)=CC=2)C1=O |&1:12,14,33,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C33H35N6O7P/c1-22-31-38(29(40)21-36(2)39(31)33(42)35-19-24-8-4-3-5-9-24)28(18-23-13-15-27(16-14-23)46-47(43,44)45)32(41)37(22)20-26-11-6-10-25-12-7-17-34-30(25)26/h3-17,22,28,31H,18-21H2,1-2H3,(H,35,42)(H2,43,44,45)/t22-,28-,31-/m0/s1 |
| InChiKey | VHOZWHQPEJGPCC-AZXNYEMZSA-N |
| CID | 71509318 |
| Short Description | Wnt/CREB inhibitor |
References
- H Okazaki et al. The novel inhibitor PRI-724 for Wnt/β-catenin/CBP signaling ameliorates bleomycin-induced pulmonary fibrosis in mice. Exp. Lung Res. 2019,45, 188-199.
- Y Osawa et al. Programmed cell death ligand 1 (PD-L1) blockade attenuates metastatic colon cancer growth in cAMP-response element-binding protein (CREB)-binding protein (CBP)/β-catenin inhibitor-treated livers. Oncotarget 2019, 10, 3013-3026.
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