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IWP-2
Axon 4370
CAS:
686770-61-6
Purity:
98%
- Soluble in DMSO
- MF: C22H18N4O2S3
- MW: 466.6
Description
IWP-2 is an inhibitor of Wnt signaling (IC50 value of 27 nM) by inhibiting porcupine (Porcn), a member of the membrane-bound O-acyltransferases (MBOAT) protein family. ESC self-renewal was suppressed by IWP-2. Additionally, IWP-2 specifically inhibited CK1δ with a IC50 value of 317 nM.
More Information
| Parent CAS No. | 686770-61-6 |
|---|---|
| Chemical Name | N-(6-Methyl-1,3-benzothiazol-2-yl)(7-oxo-6-phenyl-1-thia-4,6-diaza-5-indanylthio)acetamide |
| SMILES | N1C2CCSC=2C(=O)N(C2=CC=CC=C2)C=1SCC(NC1=NC2=CC=C(C)C=C2S1)=O |
| MFCD | MFCD04457599 |
| InChi | InChI=1S/C22H18N4O2S3/c1-13-7-8-15-17(11-13)31-21(23-15)25-18(27)12-30-22-24-16-9-10-29-19(16)20(28)26(22)14-5-3-2-4-6-14/h2-8,11H,9-10,12H2,1H3,(H,23,25,27) |
| InChiKey | WRKPZSMRWPJJDH-UHFFFAOYSA-N |
| CID | 2155128 |
| Short Description | Porcn inhibitor |
References
- B Chen et al. Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. Nat Chem Biol. 2009 Feb;5(2):100-7.
- D ten Berge et al. Embryonic stem cells require Wnt proteins to prevent differentiation to epiblast stem cells. Nat Cell Biol. 2011 Aug 14;13(9):1070-5.
- B García-Reyes et al. Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε. J Med Chem. 2018 May 10;61(9):4087-4102.
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