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Sonepiprazole hydrochloride
- PNU 101387
Axon 2115
- Parent CAS: 170858-33-0
- Optical Purity: Optically pure
- Soluble in DMSO
- MF: C21H27N3O3S.HCl
- MW: 437.98
Description
Sonepiprazole hydrochloride (PNU 101387) is a highly selective dopamine D4 receptor antagonist with high affinity for D4 receptors, reported Ki of 10 nM in clonal cell-line assays. It effectively exhibits no measurable binding affinity (Ki >2000 nM) for other dopamine receptor subtypes (D1, D2, D3, D5}, nor does it cross-react with other major neurotransmitter families like noradrenaline, serotonin, or histamine.
Dopamine D4 signaling is relevant to neuropsychiatric pharmacology, reward circuitry and antipsychotic drug discovery. Sonepiprazole is useful for probing D4-selective receptor biology and differentiating D4 effects from D2/D3 pharmacology.
Key Features
- Selective dopamine D4 receptor antagonist
- High-affinity binding to D4 receptors (Ki = 10 nM)
- Ki > 2000 nM at other dopamine receptor subtypes in reported assays
- Useful CNS receptor pharmacology probe
Applications
- D4 receptor binding studies
- Dopaminergic signaling research
- Antipsychotic mechanism studies
- Neuropsychiatric disease model assays
More Information
| Parent CAS No. | 170858-33-0 |
|---|---|
| Chemical Name | (S)-4-(4-(2-(isochroman-1-yl)ethyl)piperazin-1-yl)benzenesulfonamide hydrochloride |
| extra_info | . |
| SMILES | C1(S(N)(=O)=O)=CC=C(N2CCN(CC[C@@H]3OCCC4=CC=CC=C43)CC2)C=C1.Cl |&1:14,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C21H27N3O3S.ClH/c22-28(25,26)19-7-5-18(6-8-19)24-14-12-23(13-15-24)11-9-21-20-4-2-1-3-17(20)10-16-27-21;/h1-8,21H,9-16H2,(H2,22,25,26);1H/t21-;/m0./s1 |
| InChiKey | LMERFPJRWBLXAM-BOXHHOBZSA-N |
| CID | 91826499 |
| Short Description | D4 antagonist |
Sonepiprazole hydrochloride (PNU 101387)
selective dopamine D4 receptor antagonist
Sonepiprazole hydrochloride
PNU 101387
PNU101387
U 101387
DRD4
dopamine D4 receptor
dopamine
Antagonist
dopamine signaling
serotonin signaling
histamine signaling
D4 receptor binding studies
Dopaminergic signaling research
Antipsychotic mechanism studies
Neuropsychiatric disease model assays
addiction research
drug discovery
GPCR pharmacology
receptor selectivity
signal transduction
CNS
Axon Medchem
Axon 2115
Supplier
Vendor
References
- PA Broderick et al. Clozapine, haloperidol, and the D4 antagonist PNU-101387G: in vivo effects on mesocortical, mesolimbic, and nigrostriatal dopamine and serotonin release. J. Neural. Transm. 1998, 105(6-7), 749-767.
- KM Merchant et al. Pharmacological characterization of U-101387, a dopamine D4 receptor selective antagonist. J. Pharmacol. Exp. Ther. 1996, 279(3), 1392-1403.
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