Dofetilide - UK 68798

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 2103

CAS [115256-11-6]

MF C19H27N3O5S2
MW 441.56

Purity: 99%
Soluble in 0.1N HCl(aq) and DMSO

Dofetilide

Description

Potent and selective potassium channel blocker, specific on subunit Kv11.1 (hERG) channel; selectively inhibits the rapid delayed-rectifier K+ current (IKr); a class III antiarrhythmic

M Gwilt et al. UK-68,798: a novel, potent and highly selective class III antiarrhythmic agent which blocks potassium channels in cardiac cells. J. Pharmacol. Expe. Ther. 1991, 256(1), 318-324.

C Torp-Pedersen et al. Dofetilide in patients with congestive heart failure and left ventricular dysfunction. N. Engl. J. Med. 1999, 341(12), 857-865.

Kv11.1 (hERG) channel blocker

Chemical name

N-(4-(2-(methyl(2-(4-(methylsulfonamido)phenoxy)ethyl)amino)ethyl)phenyl)methanesulfonamide

Parent CAS No.

[115256-11-6]

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Dofetilide - UK 68798

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Dofetilide - UK 68798

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