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BAY K 8644
- (±)-BAY K 8644
- Soluble in DMSO and EtOH
- MF: C16H15F3N2O4
- MW: 356.3
Description
A L-type calcium channel activator that facilitates Ca2+ influx specifically at voltage-gated Ca2+ channels, thereby causing vasoconstrictor and positive inotropic effects.
It is used primarily as a research tool. Bay-K8644 in combination of BIX-01294 (Axon 1692) enables reprogramming of Oct4/Klf4-transduced mouse embryonic fibroblasts.
Its two enantiomers, (R)-(+)-BAY-K8644 (Axon 1758) and (S)-(-)-BAY-K8466 (Axon 1759), are also available.
More Information
| Parent CAS No. | 71145-03-4 |
|---|---|
| Chemical Name | methyl 2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-1,4-dihydropyridine-3-carboxylate |
| SMILES | C1C=CC=C(C2C(C(OC)=O)=C(C)NC(C)=C2[N+]([O-])=O)C=1C(F)(F)F |
| MFCD | MFCD00036697 |
| InChi | InChI=1S/C16H15F3N2O4/c1-8-12(15(22)25-3)13(14(21(23)24)9(2)20-8)10-6-4-5-7-11(10)16(17,18)19/h4-7,13,20H,1-3H3 |
| InChiKey | ZFLWDHHVRRZMEI-UHFFFAOYSA-N |
| CID | 2303 |
| Short Description | Ca channel activator |
References
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