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HDAC6 inhibitor ISOX
- Soluble in DMSO
- MF: C22H30N4O6
- MW: 446.5
Description
HDAC6 inhibitor ISOX is a potent and selective histone deacetylase 6 (HDAC6) inhibitor with IC50 values of 2.4 nM for HDAC6 and 71 nM for HDAC1. The compound exhibits strong selectivity for HDAC6 and serves as a valuable tool for studying HDAC6-dependent cellular processes.
HDAC6 is a unique cytoplasmic histone deacetylase that regulates acetylation of non-histone proteins including α-tubulin, HSP90, and cortactin. Through its roles in protein degradation, cytoskeletal dynamics, intracellular transport, and stress responses, HDAC6 has emerged as an important target in neurodegenerative disorders, cancer, inflammation, and protein aggregation diseases. HDAC6 inhibitor ISOX enables selective interrogation of HDAC6 biology while minimizing inhibition of class I HDACs.
Key Features
- Potent and selective HDAC6 inhibitor
- IC50: 2.4 nM for HDAC6
- IC50: 71 nM for HDAC1
- Selective tool for HDAC6-dependent signaling
- Useful probe for epigenetic and protein homeostasis research
Applications
- HDAC6 biology and epigenetics research
- Protein degradation and proteostasis studies
- Neurodegeneration and protein aggregation research
- Cancer biology and target validation investigations
- Cytoskeletal regulation and intracellular transport studies
More Information
| Parent CAS No. | 1045792-66-2 |
|---|---|
| Chemical Name | tert-butyl 4-(3-(7-(hydroxyamino)-7-oxoheptylcarbamoyl)isoxazol-5-yl)phenylcarbamate |
| SMILES | C(C1=NOC(C2C=CC(NC(=O)OC(C)(C)C)=CC=2)=C1)(=O)NCCCCCCC(=O)NO |
| MFCD | MFCD17010286 |
| InChi | InChI=1S/C22H30N4O6/c1-22(2,3)31-21(29)24-16-11-9-15(10-12-16)18-14-17(26-32-18)20(28)23-13-7-5-4-6-8-19(27)25-30/h9-12,14,30H,4-8,13H2,1-3H3,(H,23,28)(H,24,29)(H,25,27) |
| InChiKey | WWGBHDIHIVGYLZ-UHFFFAOYSA-N |
| CID | 24951314 |
| Short Description | HDAC6 inhibitor |
References
- KV Butler et al. Rational Design and Simple Chemistry Yield a Superior, Neuroprotective HDAC6 Inhibitor, Tubastatin A. J. Am. Chem. Soc. 2010, 132, 10842–10846.
- AP Kozikowski et al. Use of the Nitrile Oxide Cycloaddition (NOC) Reaction for Molecular Probe Generation: A New Class of Enzyme Selective Histone Deacetylase Inhibitors (HDACIs) Showing Picomolar Activity at HDAC6. J. Med. Chem. 2008, 51, 4370–4373.
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