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NNC 756

 - Odapipam
Axon 1405
CAS:  131796-63-9
  • Optical Purity:  99% e.e.
  • Soluble in DMSO
  • MF:  C19H20ClNO2
  • MW:  329.82

Description

NNC 756 (Odapipam) is a very high-affinity and selective dopamine D1 receptor antagonist with a reported receptor binding Kd value of 0.18 nM. It is more potent than SCH23390 (Axon 4341).

Odapipam blocks D1-like receptor signaling and has been used in receptor-occupancy and neuroimaging studies. It is a useful comparator for dopaminergic motor, cognitive and psychosis-related pathways.

Key Features

  • High-affinity dopamine D1 receptor antagonist
  • Reported Kd: 0.18 nM
  • Suitable for D1 receptor occupancy studies
  • Greater D1 antagonist potency than many classical references

Applications

  • D1 receptor binding and functional assays
  • Dopamine receptor occupancy research
  • Motor and cognitive pathway studies
  • Psychosis and antipsychotic pharmacology models

More Information

Parent CAS No. 131796-63-9
Chemical Name (S)-(+)-8-Chloro-5-(2,3-dihydro-benzofuran-7-yl)-3-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ol
SMILES [C@@H]1(C2C3OCCC=3C=CC=2)C2C=C(O)C(Cl)=CC=2CCN(C)C1 |&1:0,r|
MFCD N.A.
InChi InChI=1S/C19H20ClNO2/c1-21-7-5-13-9-17(20)18(22)10-15(13)16(11-21)14-4-2-3-12-6-8-23-19(12)14/h2-4,9-10,16,22H,5-8,11H2,1H3/t16-/m1/s1
InChiKey SKMVRXPBCSTNKE-MRXNPFEDSA-N
CID 132421
Short Description D1 antagonist

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