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NS 30678 hydrochloride
- Parent CAS: 1193707-15-1
- Optical Purity: Optically pure
- Soluble in water and DMSO
- MF: C12H16ClNO4S.HCl
- MW: 342.24
Description
Dopamine D2 receptor ligand with surmountable/competitive-like D2 antagonist properties (Ki and IC50 values of value 9.7 nM and 7 nM, repectively in HEK-hD2L-Gαqi5 cells), equipotent to Haloperidol and Risperidone (Axon 1454). NS30678 shows rapid recovery and dopamine responsiveness within 5 min after administration.
More Information
| Parent CAS No. | 1193707-15-1 |
|---|---|
| Chemical Name | (S)-N-((5-chloro-7-(methylsulfonyl)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)ethanamine hydrochloride |
| SMILES | C1(S(C)(=O)=O)C=C2O[C@@H](CNCC)COC2=C(Cl)C=1.Cl |&1:8,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C12H16ClNO4S.ClH/c1-3-14-6-8-7-17-12-10(13)4-9(19(2,15)16)5-11(12)18-8;/h4-5,8,14H,3,6-7H2,1-2H3;1H/t8-;/m0./s1 |
| InChiKey | ZUZLIKSHWKUMNT-QRPNPIFTSA-N |
| CID | 91826480 |
| Short Description | D2 antagonist |
References
- T. Dyhring et al. The dopaminergic stabilizers pridopidine (ACR16) and (-)-OSU6162 display dopamine D(2) receptor antagonism and fast receptor dissociation properties. Eur J Pharmacol. 2010 Feb 25;628(1-3):19-26.
- K. Sahlholm et al. Typical and atypical antipsychotics do not differ markedly in their reversibility of antagonism of the dopamine D2 receptor. Int J Neuropsychopharmacol. 2014 Jan;17(1):149-55.
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