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Amisulpride

Name: Amisulpride
SKU: 1381

- DAN 2163

Axon 1381

CAS: 71675-85-9

Purity: 99%

Soluble in 0.1N HCl(aq)

MF: C17H27N3O4S
MW: 369.48

Description

Amisulpride is a high-affinity dopamine D2 and D3 receptor antagonist with reported Ki values of 2.8 nM at D2 and 3.2 nM at D3.

Amisulpride is an atypical antipsychotic reference compound used to study D2-family receptor blockade in mesolimbic and striatal pathways. Its pharmacology is relevant to psychosis, prolactin regulation and dopamine-dependent behavioral responses.

Key Features

High-affinity D2/D3 receptor antagonist
Ki: 2.8 nM (D2) and 3.2 nM (D3)
Clinically established atypical antipsychotic pharmacology
Useful for mesolimbic versus striatal dopamine studies

Applications

D2 and D3 receptor binding assays
Antipsychotic mechanism research
Dopamine-dependent behavioral models
Prolactin and neuroendocrine signaling studies

More Information

Certificate of Analysis (B1)

Material Safety Data Sheet (B1)

Parent CAS No.	71675-85-9
Chemical Name	4-Amino-5-ethanesulfonyl-N-(1-ethyl-pyrrolidin-2-ylmethyl)-2-methoxy-benzamide
SMILES	C1(C(=O)NCC2CCCN2CC)C=C(C(N)=CC=1OC)S(=O)(=O)CC
MFCD	MFCD00866691
InChi	InChI=1S/C17H27N3O4S/c1-4-20-8-6-7-12(20)11-19-17(21)13-9-16(25(22,23)5-2)14(18)10-15(13)24-3/h9-10,12H,4-8,11,18H2,1-3H3,(H,19,21)
InChiKey	NTJOBXMMWNYJFB-UHFFFAOYSA-N
CID	2159
Short Description	D2/3 antagonist

Amisulpride high-affinity D2/D3 receptor antagonist DAN 2163 DAN2163 DAN-2163 DRD3 DRD2 D2/D3 receptor D2 D3 Antagonist dopamine signaling D2 and D3 receptor binding assays Antipsychotic mechanism research Dopamine-dependent behavioral models Prolactin and neuroendocrine signaling studies behavioral neuroscience GPCR pharmacology signal transduction receptor pharmacology neuroscience CAS 71675-85-9 Axon Medchem Axon 1381 Supplier Vendor

References

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Amisulpride

Description

Key Features

Applications

More Information

References

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